Autoimmunity-Associated Gut Commensals Modulate Gut Permeability and Immunity in Humanized Mice
نویسندگان
چکیده
منابع مشابه
Gut Immunity: A NOD to the Commensals
The gut microbiota play critical roles in intestinal function, but the mechanisms involved remain obscure. Recent studies suggest that commensal bacteria promote immune homeostasis via the innate immune receptor Nod1.
متن کاملAutoimmunity and the Gut
Autoimmune diseases have increased dramatically worldwide since World War II. This is coincidental with the increased production and use of chemicals both in industrial countries and agriculture, as well as the ease of travel from region to region and continent to continent, making the transfer of a pathogen or pathogens from one part of the world to another much easier than ever before. In thi...
متن کاملInvestigation of Gut Permeability
Changes in the permeability of the small intestine can result in under-absorption of nutrients or the converse, over-absorption of the intestinal contents. Either condition can be described as malabsorption, although this term is more commonly used in the case of under-absorption of nutrients. A number of investigators have shown that over-absorption syndromes (increased gut permeability) are v...
متن کاملThe gut microbiota influences blood-brain barrier permeability in mice.
Pivotal to brain development and function is an intact blood-brain barrier (BBB), which acts as a gatekeeper to control the passage and exchange of molecules and nutrients between the circulatory system and the brain parenchyma. The BBB also ensures homeostasis of the central nervous system (CNS). We report that germ-free mice, beginning with intrauterine life, displayed increased BBB permeabil...
متن کاملYeasts in the gut: from commensals to infectious agents.
BACKGROUND Controversy still surrounds the question whether yeasts found in the gut are causally related to disease, constitute a health hazard, or require treatment. METHODS The authors present the state of knowledge in this area on the basis of a selective review of articles retrieved by a PubMed search from 2005 onward. The therapeutic recommendations follow the current national and intern...
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ژورنال
عنوان ژورنال: Military Medicine
سال: 2019
ISSN: 0026-4075,1930-613X
DOI: 10.1093/milmed/usy309